TY - JOUR
T1 - Nitrate in maternal drinking water during pregnancy and measures of male fecundity in adult sons
AU - Clemmensen, Pernille Jul
AU - Brix, Nis
AU - Schullehner, Jörg
AU - Gaml-Sørensen, Anne
AU - Toft, Gunnar
AU - Tøttenborg, Sandra Søgaard
AU - Ebdrup, Ninna Hinchely
AU - Hougaard, Karin Sørig
AU - Hansen, Birgitte
AU - Sigsgaard, Torben
AU - Kolstad, Henrik Albert
AU - Bonde, Jens Peter Ellekilde
AU - Ramlau-Hansen, Cecilia Høst
N1 - Publisher Copyright:
© 2022 by the authors.
PY - 2022/11
Y1 - 2022/11
N2 - Animal studies indicate deleterious effects of nitrate exposure on fecundity, but effects in humans are unknown, both for the prenatal and postnatal periods. We aimed to investigate if exposure to nitrate in maternal drinking water during the sensitive period of fetal life is associated with measures of fecundity in the adult sons. In a sub-analysis, the potential effects of nitrate exposure in adulthood were investigated. This cohort included 985 young adult men enrolled in The Fetal Programming of Semen Quality Cohort (FEPOS). Semen characteristics, testes volume and reproductive hormones were analyzed in relation to nitrate concentration in maternal drinking water, using a negative binomial regression model. The nitrate concentration in drinking water was obtained from monitoring data from Danish waterworks that were linked with the mothers’ residential address during pregnancy. The median nitrate concentration in maternal drinking water was 2 mg/L. At these low exposure levels, which are far below the World Health Organization’s (WHO) guideline value of 50 mg/L, we did not find indications of harmful effects of nitrate on the investigated measures of male fecundity.
AB - Animal studies indicate deleterious effects of nitrate exposure on fecundity, but effects in humans are unknown, both for the prenatal and postnatal periods. We aimed to investigate if exposure to nitrate in maternal drinking water during the sensitive period of fetal life is associated with measures of fecundity in the adult sons. In a sub-analysis, the potential effects of nitrate exposure in adulthood were investigated. This cohort included 985 young adult men enrolled in The Fetal Programming of Semen Quality Cohort (FEPOS). Semen characteristics, testes volume and reproductive hormones were analyzed in relation to nitrate concentration in maternal drinking water, using a negative binomial regression model. The nitrate concentration in drinking water was obtained from monitoring data from Danish waterworks that were linked with the mothers’ residential address during pregnancy. The median nitrate concentration in maternal drinking water was 2 mg/L. At these low exposure levels, which are far below the World Health Organization’s (WHO) guideline value of 50 mg/L, we did not find indications of harmful effects of nitrate on the investigated measures of male fecundity.
KW - drinking water
KW - nitrate
KW - prenatal exposure
KW - reproduction
KW - semen analysis
KW - semen quality
UR - http://www.scopus.com/inward/record.url?scp=85141882198&partnerID=8YFLogxK
U2 - 10.3390/ijerph192114428
DO - 10.3390/ijerph192114428
M3 - Article
AN - SCOPUS:85141882198
SN - 1661-7827
VL - 19
JO - International Journal of Environmental Research and Public Health
JF - International Journal of Environmental Research and Public Health
IS - 21
M1 - 14428
ER -
