Iron-catalyzed coupling of aryl grignard reagents with alkyl halides: A competitive hammett study

Anna Hedström; Ulla Bollmann; Jenny Bravidor; Per Ola Norrby

doi:10.1002/chem.201100467

Iron-catalyzed coupling of aryl grignard reagents with alkyl halides: A competitive hammett study

Anna Hedström, Ulla Bollmann, Jenny Bravidor, Per Ola Norrby

Publikation: Bidrag til tidsskrift › Artikel › Forskning › peer review

47 Citationer (Scopus)

Resumé

Competing for electrophiles: The elusive iron-catalyzed C-C coupling reaction was investigated and analyzed by a Hammett study of the nucleophilic partner. This required finding conditions in which the iron catalyst is stable in the presence of an excess of the Grignard reagent. The selectivity- determining step seems to be the transmetalation, occurring either before or after the oxidative addition step (see scheme).

Originalsprog	Engelsk
Sider (fra-til)	11991-11993
Antal sider	3
Tidsskrift	Chemistry - A European Journal
Vol/bind	17
Udgave nummer	43
DOI	https://doi.org/10.1002/chem.201100467
Status	Udgivet - 17 okt. 2011
Udgivet eksternt	Ja

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Programområde 2: Vandressourcer

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10.1002/chem.201100467Licens: Ikke-specificeret

Citationsformater

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AU - Bollmann, Ulla

AU - Bravidor, Jenny

AU - Norrby, Per Ola

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Y1 - 2011/10/17

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AB - Competing for electrophiles: The elusive iron-catalyzed C-C coupling reaction was investigated and analyzed by a Hammett study of the nucleophilic partner. This required finding conditions in which the iron catalyst is stable in the presence of an excess of the Grignard reagent. The selectivity- determining step seems to be the transmetalation, occurring either before or after the oxidative addition step (see scheme).

KW - catalysis

KW - coupling reactions

KW - Hammett plots

KW - iron

KW - reaction mechanisms

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Iron-catalyzed coupling of aryl grignard reagents with alkyl halides: A competitive hammett study

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