Household tubewell water extracted from Holocene aquifer is remaining a major drinking source for the farmer in the Red river delta in the North Vietnam. Higher levels according to WHO safety guideline (10 μg/L for Arsenic (As) and 0.4 mg/L for Manganese (Mn) were found either for arsenic or manganese in 58% of 512 wells. The average arsenic levels in groundwater are 229, 425 and 261 μg/L (P < 0.05) in three hot sports namely Dan Phuong, Ly Nhan and Hoai Duc respectively. The arsenic concentrations in the treated groundwater using sand filter tanks were reduced remarkably; they are 29, 35 and 144 μg/L (P < 0.05) respectively. At control site, Tu Liem, the average hair arsenic concentration is 0.3 mg/kg. At contaminated sites, Dan Phuong, Ly Nhan and Hoai Duc, the levels of arsenic in hair are 0.6; 0.8 and 1.4 mg/kg (P < 0.05) respectively.